Hypoglycemic activity of derivatives of succinic acid amides and hydrazides

A series of 20 substituted amides and hydrazides of succinic acid were synthesized and studied with respect to their action upon the blood glucose level in intact rats. The structure-activity relationship is considered. Substances exhibiting maximum hypoglycemic activity were additionally characteri...

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Published inĖksperimentalʹnaâ i kliničeskaâ farmacologiâ Vol. 66; no. 3; p. 36
Main Authors Dolzhenko, A V, Kotegov, V P, Godina, A T, Syropiatov, B Ia, Kolotova, N V, Koz'minykh, V O
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.05.2003
Subjects
Amides - chemistry
Amides - pharmacology
Amides - toxicity
Animals
Blood Glucose - analysis
Butyrates - chemistry
Butyrates - pharmacology
Butyrates - toxicity
Diabetes Mellitus, Experimental - blood
Female
Hydrazines - chemistry
Hydrazines - pharmacology
Hydrazines - toxicity
Hypoglycemic Agents - chemistry
Hypoglycemic Agents - pharmacology
Hypoglycemic Agents - toxicity
Lethal Dose 50
Male
Rats
Structure-Activity Relationship
Toxicity Tests, Acute
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Summary:A series of 20 substituted amides and hydrazides of succinic acid were synthesized and studied with respect to their action upon the blood glucose level in intact rats. The structure-activity relationship is considered. Substances exhibiting maximum hypoglycemic activity were additionally characterized by the acute toxicity and the hypoglycemic effect on the model of alloxan diabetes in rats. It was found that 4-aminobenzoyl hydrazide is more effective and less toxic than the reference compounds metformin and glyclazide.
ISSN:0869-2092