Morpho-functional changes of surfactant system in pulmonary tuberculosis

A complex study of different cellular and extracellular surfactant elements in the dynamics of the spontaneous course of generalized tuberculosis was made in 240 guinea-pigs and 77 patients with different forms of active pulmonary tuberculosis by using electron microscopy, biochemistry, and physical...

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Published inVestnik Rossiĭskoĭ akademii medits︠i︡nskih nauk no. 12; p. 31
Main Authors Erokhin, V V, Lepekha, L N
Format Journal Article
LanguageRussian
Published Russia (Federation) 2000
Subjects
Animals
Biomarkers
Bronchoalveolar Lavage Fluid - chemistry
Bronchoalveolar Lavage Fluid - cytology
Disease Progression
Epithelium - metabolism
Epithelium - ultrastructure
Guinea Pigs
Humans
Pulmonary Alveoli - metabolism
Pulmonary Alveoli - ultrastructure
Pulmonary Surfactants - metabolism
Pulmonary Surfactants - ultrastructure
Tuberculosis, Pulmonary - metabolism
Tuberculosis, Pulmonary - pathology
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Summary:A complex study of different cellular and extracellular surfactant elements in the dynamics of the spontaneous course of generalized tuberculosis was made in 240 guinea-pigs and 77 patients with different forms of active pulmonary tuberculosis by using electron microscopy, biochemistry, and physical chemistry. A diagnostic scheme was proposed for life-time assessment of surfactant in bronchoalveolar lavage specimens. Three degrees of changes in surfactant were identified; 1) adaptive rearrangement of its elements developing in local surfactant damages; 2) significantly impaired type 2 alveolocyte production of surfactant, which affects its biochemical composition and capacity of forming characteristic structures; 3) common morphological, biochemical, surface-active signs of surfactant decompensation, profound metabolic disturbances, alveolar epithelial destruction with cleared alveolocytes found in the lavage.
ISSN:0869-6047