Diagnostic and therapeutic aspects of dialysis-related amyloidosis

The definitive diagnosis of dialysis-related amyloidosis based on histologic findings suffers from invasive surgical procedure and punctual information. Imaging techniques: ultrasonography, X-ray, computed tomography or magnetic resonance are relatively nonspecific and not sensitive enough. Scintigr...

Full description

Saved in:
Bibliographic Details
Published inPrzeglad lekarski Vol. 63; no. 7; p. 567
Main Author Kopeć, Jerzy
Format Journal Article
LanguagePolish
Published Poland 2006
Subjects
Adsorption
Amyloidosis - blood
Amyloidosis - etiology
Amyloidosis - therapy
beta 2-Microglobulin - metabolism
Biocompatible Materials
Blood Component Removal - instrumentation
Blood Component Removal - methods
Cellulose - therapeutic use
Hemodiafiltration - methods
Hemoperfusion - methods
Humans
Membranes, Artificial
Renal Dialysis - adverse effects
Renal Dialysis - methods
Online AccessGet more information

Cover

More Information
Summary:The definitive diagnosis of dialysis-related amyloidosis based on histologic findings suffers from invasive surgical procedure and punctual information. Imaging techniques: ultrasonography, X-ray, computed tomography or magnetic resonance are relatively nonspecific and not sensitive enough. Scintigraphy using radio-labelled beta-2-microglobulin currently represents the most specific method to noninvasively diagnosis dialysis-related amyloidosis. Available therapeutic methods include the removal of BMG and palliation of symptoms. Hemodialysis high-flux and hemodiafiltration based on convection are more effective in elimination of BMG than standard hemodialysis with diffusive transport as a dominant mechanism. Use of the adsorption columns Lixelle reduces plasma BMG concentration and leads to clinical improvement of DRA. Medical therapy consists of the use of low dose corticosteroids and non-steroidal anti-inflammatory drugs. Surgical therapy is often necessary in the late stages of DRA. Renal transplantation is still the optimal method of DRA treatment.
ISSN:0033-2240