Pathogenesis of ophthalmoherpes basing on the analysis of enzymes of the eye tissue and fluids

To specify mechanisms of pathology development, we studied the activity of lysosomal glycosides in rabbit ocular tissues in experimental ophthalmoherpes. Rabbits with herpetic kepatitis show activation of beta-glucuronidase, beta-glycosidase, alpha-mannosidase in cornial epithelium and stroma, iris,...

Full description

Saved in:
Bibliographic Details
Published inPatologicheskaia fiziologiia i eksperimental'naia terapiia no. 2; p. 16
Main Authors Terekhina, N A, Petrovich, Iu A, Reuk, S E
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.04.2008
Subjects
Animals
Eye - enzymology
Eye - pathology
Eye - virology
Glycoside Hydrolases - metabolism
Glycosides - metabolism
Keratitis, Herpetic - enzymology
Keratitis, Herpetic - pathology
Keratitis, Herpetic - virology
Lysosomes - enzymology
Lysosomes - virology
Rabbits
Simplexvirus - enzymology
Tears - enzymology
Tears - metabolism
Viral Proteins - metabolism
Online AccessGet more information

Cover

More Information
Summary:To specify mechanisms of pathology development, we studied the activity of lysosomal glycosides in rabbit ocular tissues in experimental ophthalmoherpes. Rabbits with herpetic kepatitis show activation of beta-glucuronidase, beta-glycosidase, alpha-mannosidase in cornial epithelium and stroma, iris, aqueous humor of herpes-infected and contralateral eye. The activity of the above three glycosidases in the tears of children with herpetic keratitis was enhanced. If their activity does not regress after the treatment, ophthalmoherpes recurrence may be expected in the near future. For realization of its genetic program herpes simplex virus in infected cells activates synthesis of acid glycosidases this leading to degradation of cornial cell membranes, virus spread in the tissues and release of lysosomal enzymes into tear fluid.
ISSN:0031-2991