Morphological characteristics of the testicles of male Wistar rats intoxicated with morphine

Experimental study of the effect of morphine on reproductive organs was made in Wistar rats. In the experimental animals from Group 1, 1% morphine solution was intraperitoneally injected in increasing doses during 10 days while in Group 2 animals were taught to administer morphine themselves during...

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Bibliographic Details
Published inArkhiv patologii Vol. 70; no. 6; p. 41
Main Authors Mkhitarov, V A, Lun'kova, L K
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.11.2008
Subjects
Animals
Corticosterone - blood
Estradiol - blood
Follicle Stimulating Hormone - blood
Injections, Intraperitoneal
Injections, Intravenous
Luteinizing Hormone - blood
Male
Morphine - administration & dosage
Morphine - toxicity
Rats
Rats, Wistar
Spermatogenesis
Testis - drug effects
Testis - pathology
Testosterone - blood
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Summary:Experimental study of the effect of morphine on reproductive organs was made in Wistar rats. In the experimental animals from Group 1, 1% morphine solution was intraperitoneally injected in increasing doses during 10 days while in Group 2 animals were taught to administer morphine themselves during 28 days. Morphological and morphometric studies were conducted. The plasma levels of follicle-stimulating hormone, luteinizing hormone, corticosterone, testosterone, and estradiol were measured by enzyme immunoassay. It was ascertained that there was a progressive inhibition of both hormonopoietic and spermatogenic functions depending on the duration of morphine use.
ISSN:0004-1955