A case of synchronous gastric and hepatocellular carcinoma successfully treated by TS-1 and hepatic arterial infusion chemotherapy (HAI) of low-dose CDDP

• Published in: Gan to kagaku ryoho Vol. 32; no. 13; p. 2121
• Main Authors: Terakura, Masanobu, Ikawa, Sumito, Kubota, Daisuke, Katsuragi, Kunihiro, Ohba, Kazuki, I, Sanhon, Matsuyama, Mitsuharu
• Format: Journal Article
• Language: Japanese
• Published: Japan 01.12.2005
• Subjects: Administration, Oral; Aged; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Carcinoma, Hepatocellular - drug therapy; Cisplatin - administration & dosage; Combined Modality Therapy; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Combinations; Gastrectomy; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver Neoplasms - drug therapy; Liver Neoplasms - secondary; Lymph Nodes - pathology; Lymphatic Metastasis; Male; Neoplasms, Multiple Primary - drug therapy; Oxonic Acid - administration & dosage; Pyridines - administration & dosage; Stomach Neoplasms - drug therapy; Stomach Neoplasms - pathology; Stomach Neoplasms - surgery; Tegafur - administration & dosage
• ISSN: 0385-0684

A 75-year-old man underwent distal gastrectomy for advanced gastric cancer with liver and lymph node metastases and synchronous hepatocellular carcinoma in April 2004. HAI with low-dose CDDP/TS-1 combination therapy was initiated after gastrectomy. Liver and lymph node metastases decreased significantly, with achievement of a partial response (PR) and a complete response (CR), respectively, and the hepatocellular carcinoma was reduced to 54.1% of its initial size after 3 sessions of this chemotherapy. These results suggested that combined chemotherapy with TS-1 and HAI with low-dose CDDP was not only useful for liver and lymph node metastases from gastric cancer, but for hepatocellular carcinoma as well.