Monoamine, GABA, and glutamergic mechanisms of the anterior hypothalamus in anti-aversive effects of sedative and selective drugs in various models of anxiety

The experiments using "illuminated site" and "threatening situation" avoidance tests on rats microinjected with GABA, glutamic acid, monoamines and their agonists and antagonists, as well as anxiosedative and anxioselective agents into the anterior hypothalamus revealed functiona...

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Bibliographic Details
Published inĖksperimentalʹnaâ i kliničeskaâ farmacologiâ Vol. 64; no. 2; p. 20
Main Authors Talalaenko, A N, Gordienko, D V, Markova, O P, Goncharenko, N V, Pankrat'ev, D V
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.03.2001
Subjects
Animals
Anti-Anxiety Agents - pharmacology
Anxiety - drug therapy
Anxiety - psychology
Avoidance Learning - drug effects
Biogenic Monoamines - antagonists & inhibitors
Biogenic Monoamines - pharmacology
Chlordiazepoxide - pharmacology
Disease Models, Animal
Excitatory Amino Acid Agonists - pharmacology
Excitatory Amino Acid Antagonists - pharmacology
GABA Agonists - pharmacology
GABA Antagonists - pharmacology
gamma-Aminobutyric Acid - analogs & derivatives
gamma-Aminobutyric Acid - pharmacology
Glutamic Acid - pharmacology
Hypnotics and Sedatives - pharmacology
Hypothalamus, Anterior - drug effects
Injections, Intraperitoneal
Male
Microinjections
Piperazines - pharmacology
Pyrimidines - pharmacology
Rats
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Summary:The experiments using "illuminated site" and "threatening situation" avoidance tests on rats microinjected with GABA, glutamic acid, monoamines and their agonists and antagonists, as well as anxiosedative and anxioselective agents into the anterior hypothalamus revealed functional ambiguity in the neurochemical profile of this limbic brain formation in the anxiety states of various aversive genesis. Preliminary intraperitoneal injection of the monoamine and GABA antagonists, followed by the local administration of the antianxiety drugs studied, showed that the antiaversive action of chlordiazepoxide, fenibut, and indoter is manifested in both anxiety models via a GABAergic mechanism in the anterior hypothalamus. The anxiolytic effect of campiron is manifested only under negative-stressor zoosocial conditions and is mediated by the serotoninergic systems of this limbic brain formation.
ISSN:0869-2092