Effect of different drug dosage to activate blood circulation and to nourish qi on cardiac function and structure of congestive heart failure rats after acute myocardial infarction

• Published in: Zhongguo zhongyao zazhi Vol. 28; no. 5; p. 446
• Main Authors: Chen, Jin-xing, Wang, Shuo-ren, Zhao, Ming-jing, Lu, Xi-ying, Zhang, Zhuang, Qin, Ying
• Format: Journal Article
• Language: Chinese
• Published: China 01.05.2003
• Subjects: Animals; Astragalus membranaceus - chemistry; Codonopsis - chemistry; Drug Combinations; Drugs, Chinese Herbal - administration & dosage; Drugs, Chinese Herbal - isolation & purification; Drugs, Chinese Herbal - pharmacology; Heart - physiopathology; Heart Failure - etiology; Heart Failure - pathology; Heart Failure - physiopathology; Male; Myocardial Infarction - complications; Plants, Medicinal - chemistry; Rats; Rats, Sprague-Dawley; Salvia miltiorrhiza - chemistry
• ISSN: 1001-5302

To observe the effect of different drug dosage to activate blood circulation and to nourish Qi on cardiac function and structure of heart failure rats after acute myocardial infarction. The congestive heart failure post cardiac infarction rats models subjected to left coronary occlusion were made and given different dosage of drug of Huoxue Yiqi and captopril (positive control) from 4 weeks to 8 weeks after operation. The cardiac function before and after using drugs were observed by impedance methods. Treated by different dosage of drug of Huoxue Yiqi and captopil, cardiac function of heart failure rats after acute myocardial infarction improved, SV, CO, CI(P < 0.01); at the same time, prescription of Huoxue Yiqi and Qixue could improve the model rats' heart coefficient, VS SHAM(P > 0.05), but prescription of Yiqi Huoxue and captopril could not improve it. Drug to activate blood circulation and to increase qi can treat heart failure rats after acute myocardial infarction, through improving their function and