Endothelial cell-based methods for the detection of cyanobacterial anti-inflammatory and wound-healing promoting metabolites

Acute lung injury is accompanied by an increased endothelial chemokine production and adhesion molecule expression, which may result in an extensive neutrophil infiltration. Moreover, a destruction of the alveolar epithelium and capillary endothelium may result in permeability edema. As such, the se...

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Published inDrug metabolism letters Vol. 1; no. 4; p. 254
Main Authors Wiesner, Christoph, Kopecky, Jiri, Pflueger, Maren, Hundsberger, Harald, Entler, Barbara, Kleber, Christoph, Atzler, Josef, Hrouzek, Pavel, Stys, Dalibor, Lukesova, Alena, Schuett, Wolfgang, Lucas, Rudolf
Format Journal Article
LanguageEnglish
Published United Arab Emirates 01.12.2007
Subjects
Acute Lung Injury - drug therapy
Acute Lung Injury - physiopathology
Anti-Inflammatory Agents - isolation & purification
Anti-Inflammatory Agents - pharmacology
Cell Line
Endothelial Cells - drug effects
Endothelial Cells - metabolism
Gene Expression Regulation
Humans
Intercellular Adhesion Molecule-1 - metabolism
Models, Biological
Neutrophil Infiltration - drug effects
Nostoc - chemistry
Nostoc - metabolism
Pulmonary Alveoli - drug effects
Pulmonary Alveoli - physiopathology
Wound Healing - drug effects
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Summary:Acute lung injury is accompanied by an increased endothelial chemokine production and adhesion molecule expression, which may result in an extensive neutrophil infiltration. Moreover, a destruction of the alveolar epithelium and capillary endothelium may result in permeability edema. As such, the search for novel anti-inflammatory substances, able to downregulate these parameters as well as the tissue damage holds therapeutic promise. We therefore describe here the use of human endothelial cell-based in vitro assays for the detection of anti-inflammatory and wound-healing metabolites from cyanobacteria.
ISSN:1874-0758