Traditional Chinese herbs against hypertension enhance memory acquisition

Recent findings of a link between high blood pressure (BP) and dementia have given new prospects. The aim of this study is to analyze a mixture of Chinese herbs, Tianma Gouteng Decoction (TGD), which was traditionally used to treat hypertension, and investigate its relation to ameliorating cognitive...

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Bibliographic Details
Published inThe American journal of Chinese medicine (1979) Vol. 33; no. 5; p. 787
Main Authors Ho, Shih-Ching, Ho, Yueh-Feng, Lai, Tzung-Hsien, Liu, Tsu-Hwie, Wu, Rey-Yih
Format Journal Article
LanguageEnglish
Published Singapore 2005
Subjects
Amnesia - chemically induced
Amnesia - drug therapy
Animals
Antihypertensive Agents - pharmacology
Antihypertensive Agents - therapeutic use
Avoidance Learning - drug effects
Drugs, Chinese Herbal - pharmacology
Drugs, Chinese Herbal - therapeutic use
Hypertension - drug therapy
Male
Memory - drug effects
Mice
Mice, Inbred ICR
Phytotherapy
Scopolamine Hydrobromide
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Summary:Recent findings of a link between high blood pressure (BP) and dementia have given new prospects. The aim of this study is to analyze a mixture of Chinese herbs, Tianma Gouteng Decoction (TGD), which was traditionally used to treat hypertension, and investigate its relation to ameliorating cognitive impairment. We discovered that TGD also had properties involving enhancement of memory acquisition (learning) skills in mice, but not memory consolidation. It was observed that TGD could prolong the step-through latency at doses of 1.0 and 2.5 g/kg on passive avoidance task in mice. TGD could be developed further to treat mice with amnesia, which was induced by scopolamine at the same dose under long-term (8 days) administration.
ISSN:0192-415X