HLA-DPB1 gene analysis in haematopoietic stem cell transplantations

The HLA-DPB1 gene is probably one of HLA class II genes affecting the haematopoietic stem cell transplantation. The aim of the study was to analyse the HLA-DPB1 gene and its match/mismatch in patients transplanted from unrelated HSC donors. The PCR-SSP method was used for the typing of the HLA syste...

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Bibliographic Details
Published inČasopis lékařů českých Vol. 145; no. 2; p. 126
Main Authors Vraná, M, Dobrovolná, M, Cetkovský, P, Nazarová, S, Vondrácková, H, Sedlácek, P
Format Journal Article
LanguageCzech
Published Czech Republic 2006
Subjects
Adult
Child
Gene Frequency
Hematopoietic Stem Cell Transplantation
Histocompatibility Testing
HLA-DP Antigens - genetics
HLA-DP beta-Chains
Humans
Tissue Donors
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Summary:The HLA-DPB1 gene is probably one of HLA class II genes affecting the haematopoietic stem cell transplantation. The aim of the study was to analyse the HLA-DPB1 gene and its match/mismatch in patients transplanted from unrelated HSC donors. The PCR-SSP method was used for the typing of the HLA system. The cohort consisted of 201 pairs of patient/unrelated HSC donor. Match in HLA-A, -B, -Cw, -DRBI and -DQBI (e.g. 10/10 match) was found in 81 pairs. The HLA-DPBI was tested in them. 18 different HLA-DPBI alleles were identified in this cohort. Complete match (e.g.12/12) was detected in 3% of the 201 analysed pairs only. The probability of finding 12/12 matching unrelated HSC donor is limited due to the high percentage of mismatches and inaccessibility of previous HLA-DPB1 results.
ISSN:0008-7335