Immunological status of patients with epidemic parotitis

Immunosuppression was detected in six patients with parotitis. The proliferation of peripheral blood mononuclear cells, NK activity, and CD4/CD8 index decreased, while the production of tumor necrosis factor alpha and interleukin 1 beta increased on day 1 after clinical manifestation of mumps. The c...

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Bibliographic Details
Published inVoprosy virusologiĭ Vol. 46; no. 3; p. 30
Main Authors Agafonov, A P, Strel'tsova, M A, Susloparov, I M, Ignat'ev, G M
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.05.2001
Subjects
Child
Humans
Immunity, Innate
Immunosuppression
Interleukin-1 - immunology
Male
Mumps - immunology
Mumps virus - immunology
Mumps virus - isolation & purification
T-Lymphocyte Subsets - immunology
Tumor Necrosis Factor-alpha - immunology
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Summary:Immunosuppression was detected in six patients with parotitis. The proliferation of peripheral blood mononuclear cells, NK activity, and CD4/CD8 index decreased, while the production of tumor necrosis factor alpha and interleukin 1 beta increased on day 1 after clinical manifestation of mumps. The clinical diagnosis of mumps was confirmed by serological analysis of paired sera. Besides parotitis virus, herpes simplex type 1 virus was detected in two saliva samples by the polymerase chain reaction. Herpes (lip vesicles) manifested in these patients on days 8 and 11 after manifestation of parotitis.
ISSN:0507-4088