EGF-dependent association of 20S-proteasome and alpha-RNP particles with the epidermal growth factor receptor in A-431 cells

Here we demonstrate that the epidermal growth factor (EGF) induces association of prosomes (20S-proteasomes) with its receptor in A-431 cells. Additionally, ligand-dependent association of ribonucleoprotein particles (alpha-RNP), containing small ALU-like RNA, with the EGF receptor was demonstrated....

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Bibliographic Details
Published inT͡S︡itologii͡a Vol. 40; no. 11; p. 954
Main Authors Konstantinova, I M, Wetzker, R, Burova, E B, Vasilenko, K P, Turoverova, L V, Volkova, I V, Ivanova, V A, Teslenko, L V, Nikol'skiĭ, N N
Format Journal Article
LanguageRussian
Published Russia (Federation) 1998
Subjects
Cysteine Endopeptidases - metabolism
Gene Expression Regulation, Enzymologic - physiology
Humans
Multienzyme Complexes - metabolism
Particle Size
Proteasome Endopeptidase Complex
Receptor, Epidermal Growth Factor - metabolism
Ribonucleoproteins - metabolism
Tumor Cells, Cultured
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Summary:Here we demonstrate that the epidermal growth factor (EGF) induces association of prosomes (20S-proteasomes) with its receptor in A-431 cells. Additionally, ligand-dependent association of ribonucleoprotein particles (alpha-RNP), containing small ALU-like RNA, with the EGF receptor was demonstrated. A suggestion has been put forward on the involvement of prosomes and alpha-RNP in the EGF signal transmission to different stages of gene expression.
ISSN:0041-3771