Electro-magnetic base technology for estremely sensitive immunosensors and DNA-chips

We report on the development of an innovative electro-magnetic base technology for estremely sensitive sensors allowing the electrical detection of biological analytes like antigenes or DNA as well as a simple multiple detection of binding forces occurring at specific bonds between proteins. The tec...

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Bibliographic Details
Published inBiomedizinische Technik Vol. 47 Suppl 1 Pt 1; pp. 213 - 216
Main Authors Gorschlüter, A, Mak, L H, Sundermeier, C, Ross, B, Knoll, M
Format Journal Article
LanguageEnglish
Published Germany 2002
Subjects
Biosensing Techniques - instrumentation
Electrochemistry - instrumentation
Electromagnetic Fields
Equipment Design
Humans
Microelectrodes
Monitoring, Immunologic - instrumentation
Oligonucleotide Array Sequence Analysis - instrumentation
Signal Processing, Computer-Assisted - instrumentation
Transducers
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Summary:We report on the development of an innovative electro-magnetic base technology for estremely sensitive sensors allowing the electrical detection of biological analytes like antigenes or DNA as well as a simple multiple detection of binding forces occurring at specific bonds between proteins. The technology is based on the strong impact of specifically captured magnetic microbeads on an electrical current generated in a fluid by a small sensor chip with an array of activated microelectrodes. The new technological principle with the on-chip detection of analytes will be suitable for large scale applications due to its mass production compatible technologies and allow an alternative way to monitor relevant substances without the consumption of critical additional solutions and reagents.
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ISSN:0013-5585
1862-278X