Comparative study of the effects of essentiale and the novel Russian hepatoprotective agent "phospholiv" in a model of acute hepatitis in rats

• Published in: Voprosy meditsinskoi khimii Vol. 44; no. 6; p. 544
• Main Authors: Ipatova, O M, Torkhovskaia, T I, Kniazhev, V A, Karuzina, I I, Bachmanova, G I, Guseva, M K, Archakov, A I
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01.11.1998
• Subjects: Acute Disease; Albumins - biosynthesis; Animals; Carbon Tetrachloride Poisoning - metabolism; Carbon Tetrachloride Poisoning - pathology; Carbon Tetrachloride Poisoning - prevention & control; Chemical and Drug Induced Liver Injury - metabolism; Chemical and Drug Induced Liver Injury - pathology; Chemical and Drug Induced Liver Injury - prevention & control; Drug Combinations; Glycyrrhizic Acid - analogs & derivatives; Glycyrrhizic Acid - therapeutic use; Hepatitis, Animal - metabolism; Hepatitis, Animal - pathology; Hepatitis, Animal - prevention & control; Liver - metabolism; Liver - pathology; Male; Phosphatidylcholines - therapeutic use; Rats; Rats, Wistar
• ISSN: 0042-8809

Curative effect of new preparation "Phospholiv", elaborated in Institute of Biomedical Chemistry, in acute CCl4 induced rat hepatit model was studied. The preparation consists of polyunsaturated phosphatidylcholine and glycyrrhizinic acid salt. Recovery of damaged biosynthesis of albumin and total cell liver RNA--by incorporation of C14-leucine and C14-orotic acid--were observed after 3 days Phospholiv administration, that showed on reparation of damaged protein-synthesis system. Label incorporation into liver fraction > 80S--that was decreased under CCl4 influence--was also restored after Phospholiv treatment, that may testify on its regenerative effect on wholeness of subcellular hepatocytes structures. Substantial decrease of morphologic damages of liver tissue was demonstrated as well. Other phospholipid preparation--known hepatoprotector Essentiale--gave some positive effects too, but Phospholiv influence on biochemical and morphological liver features were 1.5-2 fold as compared with that of Essentiale. Results show on efficiency of polyunsaturated phospholipids in the treatment of acute hepatit in rats--as a result of influence on hepatocytes cell membrane--and on preferential effect of new hepatoprotector Phospholiv.