1,3-Capryloyl-2-arachidonoyl glycerol activates alpha-secretase activity and suppresses Abeta40 secretion in A172 cells

Alzheimer's disease (AD) is characterized by the deposition of amyloid beta-peptide (Abeta), derived from amyloid precursor protein (APP). Membrane states, such as lipid components or membrane fluidity, are important for enzymes related to APP processing in meeting their substrates efficiently....

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Published inNeuroscience letters Vol. 450; no. 3; pp. 324 - 326
Main Authors Tanabe, Chiaki, Ebina, Maiko, Asai, Masashi, Futai, Eugene, Sasagawa, Noboru, Katano, Kenji, Fukami, Harukazu, Ishiura, Shoichi
Format Journal Article
LanguageEnglish
Published Ireland 06.02.2009
Subjects
Alzheimer Disease - drug therapy
Alzheimer Disease - enzymology
Amyloid beta-Peptides - antagonists & inhibitors
Amyloid beta-Peptides - secretion
Amyloid Precursor Protein Secretases - drug effects
Amyloid Precursor Protein Secretases - metabolism
Brain - drug effects
Brain - enzymology
Brain - physiopathology
Caprylates - pharmacology
Cell Line
Cell Line, Tumor
Down-Regulation - drug effects
Down-Regulation - physiology
Enzyme Activation - drug effects
Enzyme Activation - physiology
Fatty Acids, Unsaturated - metabolism
Fatty Acids, Unsaturated - pharmacology
Humans
Neurons - drug effects
Neurons - enzymology
Neurons - secretion
Peptide Fragments - antagonists & inhibitors
Peptide Fragments - secretion
Triglycerides - pharmacology
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Summary:Alzheimer's disease (AD) is characterized by the deposition of amyloid beta-peptide (Abeta), derived from amyloid precursor protein (APP). Membrane states, such as lipid components or membrane fluidity, are important for enzymes related to APP processing in meeting their substrates efficiently. We analyzed the effects of triglycerides combined with polyunsaturated fatty acids (PUFAs) and/or caprylic acids on APP proteolysis. Our results showed that 1,3-capryloyl-2-arachidonoyl glycerol (8A8) moderately increased alpha-secretase activity (18%) in A172 cells. beta-Secretase activity was not statistically significantly changed in HEK293 cells stably expressing BACE1. However, Abeta40 secretion decreased by 22%. Thus, we conclude that 8A8 is a useful lipid compound for activating alpha-secretase activity and suppressing Abeta40 secretion.
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ISSN:0304-3940
DOI:10.1016/j.neulet.2008.11.039