Modulation of the beta1-3 voltage-gated sodium channels in rat vestibular and facial nuclei after unilateral labyrinthectomy and facial nerve section: an in situ hybridization study

• Published in: Brain research. Molecular brain research. Vol. 120; no. 1; pp. 73 - 78
• Main Authors: Vassias, I, Patko, T, Vidal, P-P, de Waele, C
• Format: Journal Article
• Language: English
• Published: Netherlands 12.12.2003
• Subjects: Animals; Autoradiography; Axotomy - methods; Ear, Inner - metabolism; Ear, Inner - surgery; Facial Nerve - cytology; Facial Nerve - metabolism; Facial Nerve - surgery; In Situ Hybridization; Male; Motor Neurons - metabolism; Oligonucleotide Probes - metabolism; Otologic Surgical Procedures; Protein Subunits - metabolism; Rats; Rats, Long-Evans; Sodium Channels - metabolism; Time Factors; Vestibular Nuclei - metabolism; Vestibular Nuclei - surgery
• ISSN: 0169-328X

We investigated whether the production of the mRNAs for the auxiliary beta subunits of the Na channels are modulated in deafferented medial vestibular nucleus (MVN) and in axotomized facial motoneurons. No beta1-3 mRNAs modulation was detected at any time following unilateral labyrinthectomy in the deafferented and intact medial vestibular nucleus. In contrast, beta1 gene expression in the axotomized facial nucleus decreased compared to controls as soon as day post-lesion 3.