New derivatives of alkyl- and aminocarbonylphosphonic acids containing 3'-azido-3'-deoxythymidine

New 5'-phosphonates of 3'-azido-3'-deoxythymidine were synthesized and shown to be low-toxic and markedly active in MT-4 cell cultures infected with HIV-1.

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Bibliographic Details
Published inBioorganicheskaia khimiia Vol. 32; no. 6; p. 603
Main Authors Ias'ko, M V, Shipitsin, A V, Khandzhinskaia, A l, Shirokova, E A, Sol'ev, P N, Pliasunova, O A, Pokrovskiĭ, A G
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.11.2006
Subjects
Anti-HIV Agents - chemical synthesis
Anti-HIV Agents - chemistry
Anti-HIV Agents - pharmacology
Cell Line
HIV Infections - drug therapy
HIV-1
Humans
Organophosphonates - chemical synthesis
Organophosphonates - chemistry
Organophosphonates - pharmacology
Thymidine - chemical synthesis
Thymidine - chemistry
Thymidine - pharmacology
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Summary:New 5'-phosphonates of 3'-azido-3'-deoxythymidine were synthesized and shown to be low-toxic and markedly active in MT-4 cell cultures infected with HIV-1.
ISSN:0132-3423