Some aspects of clinical kidney transplantation from marginal cadaver donors

• Published in: Urologii͡a︡ (Moscow, Russia : 1999) no. 4; p. 16
• Main Authors: Nesterenko, I V, Vatazin, A V, Filiptsev, P Ia, Iankovoĭ, A G
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01.07.2008
• Subjects: Adult; Cadaver; Creatinine - blood; Dopamine - administration & dosage; Dopamine Agents - administration & dosage; Female; Follow-Up Studies; Graft Rejection - blood; Graft Rejection - mortality; Humans; Kidney Diseases - mortality; Kidney Diseases - surgery; Kidney Transplantation; Male; Middle Aged; Recovery of Function - drug effects; Reperfusion Injury - blood; Reperfusion Injury - mortality; Retrospective Studies; Survival Rate; Tissue Donors; Transplantation, Homologous
• ISSN: 1728-2985

The results of kidney transplantation from marginal donors were compared in two groups of patients who had received high-dose dopamine (10-35 mcg/kg/min). Group 1 consisted of 652 patients with grafts from stable donors given dopamine in doses from 0 to 10 mcg/kg/min, group 2--of 112 patients with grafts from donors given high-dose dopamine (10-35 mcg/kg/min). Mean follow-up was 52 +/- 19 months. The following parameters were compared: percent of delayed graft function, primary nonfunction transplants, acute graft rejection, graft survival, biopsy-proven ischemic-reperfusion graft injury. The rate of delayed graft function, primary non function transplants was higher in group 2 (59 and 51%, 7 and 4%, respectively). Five-year survival of the transplants and recipients was less in group 2 (68 vs. 73% and 78 vs. 71%, respectively, p < 0.05). At the end of the follow-up the level of serum creatinine was 151 +/- 50 in group 1 and 165 +/- 80 mcmol/l in group 2 (p > 0.05). Thus, despite worse results in group 2, kidney transplantation from such marginal donors can be used.