Toxicity of magnetite-dextran particles: morphological study

Females of OFI mice were given single repeated intravenous injections of magnetite-dextran nanoparticles (MD3), the total partical diameter being 49 nm, with the magnetic core diameter equal to 10-15 nm. MD3 is a superparamagnetic preparation commonly used for magnetic resonance imaging (MRI). The l...

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Bibliographic Details
Published inT͡S︡itologii͡a Vol. 42; no. 4; p. 358
Main Authors Okon, E E, Pulikan, D, Pereverzev, A E, Kudriavtsev, B N, Zhale, P
Format Journal Article
LanguageRussian
Published Russia (Federation) 2000
Subjects
Animals
Dextrans - toxicity
Female
Ferritins - metabolism
Ferrosoferric Oxide
Heart - drug effects
Iron - metabolism
Iron - toxicity
Kidney - cytology
Kidney - drug effects
Kidney - metabolism
Liver - cytology
Liver - drug effects
Liver - metabolism
Lung - cytology
Lung - drug effects
Lung - metabolism
Magnetic Resonance Imaging
Mice
Oxides - toxicity
Spleen - cytology
Spleen - drug effects
Spleen - metabolism
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Summary:Females of OFI mice were given single repeated intravenous injections of magnetite-dextran nanoparticles (MD3), the total partical diameter being 49 nm, with the magnetic core diameter equal to 10-15 nm. MD3 is a superparamagnetic preparation commonly used for magnetic resonance imaging (MRI). The liver, spleen, heart, kidney, and lung microstructures of these mice were determined after MD3 administration. Both dose- and time-dependent changes in the examined organs were compared after single and repeated MD3 doses. MD3 induces an increse in ferritine and iron levels in all the organs, the appearance of small aggregates of lymphoid cells in the liver, the appearance of iron-containing cell formations in hepatic sinusoids, presumably composed of the Kupffer cells and portal macrophages, splenomegaly, and hemostasis of spleen blood vessels. The pronounced morphological alterations have been revealed primarily in the liver and spleen after a single administration of high MD3 doses and after repeated MD3 injections. The results of The present investigation seem to narrow somewhat the safety limits of superparamagnetic iron oxide particles. Nevertheless, the degree of morphological changes in the liver and spleen in our experiments appeared to be rather low even after a single MD3 dose that exceeds approximately by 200 times a dose necessary for diagnostics in MRI.
ISSN:0041-3771