Surgical treatment of breast cancer after neoadjuvant therapy

Primary chemotherapy represents a new therapeutic strategy that allows the implementation of conservative surgical treatment in locally advanced breast cancer or in cancers measuring > 3 cm. Of 127 patients with breast cancers measuring > 2.5 cm, 86 were treated with primary chemotherapy. This...

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Bibliographic Details
Published inChirurgia italiana Vol. 55; no. 2; p. 173
Main Authors Gioffrè Florio, Maria Antonietta, Famà, Fausto, Giacobbe, Giuseppa, Pollicino, Andrea, Scarfò, Paola
Format Journal Article
LanguageItalian
Published Italy 01.03.2003
Subjects
Adult
Aged
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Breast Neoplasms - diagnostic imaging
Breast Neoplasms - drug therapy
Breast Neoplasms - psychology
Breast Neoplasms - surgery
Female
Humans
Mastectomy, Segmental
Middle Aged
Neoadjuvant Therapy - methods
Quality of Life
Retrospective Studies
Treatment Outcome
Ultrasonography
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Summary:Primary chemotherapy represents a new therapeutic strategy that allows the implementation of conservative surgical treatment in locally advanced breast cancer or in cancers measuring > 3 cm. Of 127 patients with breast cancers measuring > 2.5 cm, 86 were treated with primary chemotherapy. This consisted in the administration of the ADM + TAX protocol in 28 cases and CNF in 58 cases. Three complete responses, 8 cases of stable disease and 75 partial responses were observed. Eleven radical mastectomies and 74 conservative treatments were performed. The chemotherapy protocol enabled us to convert 87% of the patients treated to conservative treatment, thus affording a treatment that offers a better quality of life despite the existence of a voluminous cancer and is of considerable psychological help in patients suffering from cancer of the breast.
ISSN:0009-4773