Interactions between rheumatoid factors and antinuclear autoantibodies: their occurrence in a concealed state in rheumatoid disease (arthritis); effect of D-penicillamine

In this paper it is demonstrated that IgM rheumatoid factor (RF) can inhibit the detection of antinuclear antibodies (ANA) by the classical rat liver cryostat section method. This "inhibition" of IgG-ANA by IgM-RF may be due to the formation of high molecular weight complexes. It would be...

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Bibliographic Details
Published inComptes rendus hebdomadaires des séances de l'Académie des sciences. Série D. Sciences naturelles Vol. 290; no. 8; p. 575
Main Authors Mach, P S, Delbarre, F, Piatier, D
Format Journal Article
LanguageFrench
Published France 25.02.1980
Subjects
Animals
Antibodies, Antinuclear - analysis
Arthritis, Rheumatoid - immunology
Humans
Immunoglobulin G - analysis
Immunoglobulin M - metabolism
Liver - immunology
Lupus Erythematosus, Systemic - immunology
Penicillamine - pharmacology
Rats
Rheumatoid Factor - metabolism
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Summary:In this paper it is demonstrated that IgM rheumatoid factor (RF) can inhibit the detection of antinuclear antibodies (ANA) by the classical rat liver cryostat section method. This "inhibition" of IgG-ANA by IgM-RF may be due to the formation of high molecular weight complexes. It would be the same in vivo. This masking effect can explain interesting similarities and dissimilarities observed in the clinico-immunological profiles of rheumatoid arthritis and systemic lupus erythematosus. D-Penicillamine can restore ANA activity by dissociating ANA-RF complexes. A new technique is described for the detection of these masked ANA.
ISSN:0567-655X