Interethnic differences in drug protein binding and alpha 1 acid glycoprotein concentration

Interethnic differences in drug responsiveness may in part be accounted for by differences in drug disposition. We investigated the reversible binding interaction by equilibrium dialysis between a representative acidic (warfarin) and basic (lignocaine) drug and drug binding proteins in 20 healthy ag...

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Bibliographic Details
Published inIrish journal of medical science Vol. 164; no. 1; p. 26
Main Authors Hosseine, S J, Farid, R, Ghalighi, M R, Feely, J
Format Journal Article
LanguageEnglish
Published Ireland 01.01.1995
Subjects
Adolescent
Adult
Cross-Cultural Comparison
Ethnic Groups
Female
Humans
Iran
Ireland
Lidocaine - pharmacokinetics
Male
Orosomucoid - metabolism
Protein Binding
Reference Values
Warfarin - pharmacokinetics
Iran
Ireland
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Summary:Interethnic differences in drug responsiveness may in part be accounted for by differences in drug disposition. We investigated the reversible binding interaction by equilibrium dialysis between a representative acidic (warfarin) and basic (lignocaine) drug and drug binding proteins in 20 healthy age and sex matched Iranian and Irish (Caucasian) subjects. The unbound fraction of warfarin and its major binding protein albumin, were similar in the two groups. In contrast unbound lignocaine was higher in Iranian subjects (49.6 +/- 6.96 vs 37.7 +/- 51%, mean +/- SD, p < 0.05) and this was associated with lower plasma concentrations of alpha 1 acid glycoprotein (AAG, 48.8 +/- 10 vs. 60.5 +/- 8 mg/dl p < 0.01) Such alterations may result in differences in drug responsiveness in addition to predictable pharmacokinetic consequences. Protein binding should be included in comparative studies of drugs in subjects of different races.
ISSN:0021-1265
DOI:10.1007/BF02968109