Prevalence and risk factors of hepatitis C virus infection in a hospitalized population in a gastroenterology unit. Role of endoscopic biopsies

In order to study the prevalence and risk factors of HCV infection in a population hospitalized in a Gastroenterology Unit, 3,767 patients were tested for serum anti-HCV, and 2,607 filled out a questionnaire about risk factors. With the RIBA 2 test, the overall prevalence was 5.9%. Because of the ag...

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Bibliographic Details
Published inGastroentérologie clinique et biologique Vol. 19; no. 4; p. 340
Main Authors Andrieu, J, Barny, S, Colardelle, P, Maisonneuve, P, Giraud, V, Robin, E, Bréart, G, Coste, T
Format Journal Article
LanguageFrench
Published France 01.04.1995
Subjects
Adult
Aged
Biopsy - adverse effects
Endoscopy - adverse effects
Female
France
Hepatitis C - epidemiology
Hepatitis C - etiology
Hepatitis C - transmission
Hospital Units
Humans
Liver Diseases - complications
Male
Middle Aged
Odds Ratio
Prevalence
Risk Factors
Substance-Related Disorders - complications
Transfusion Reaction
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Summary:In order to study the prevalence and risk factors of HCV infection in a population hospitalized in a Gastroenterology Unit, 3,767 patients were tested for serum anti-HCV, and 2,607 filled out a questionnaire about risk factors. With the RIBA 2 test, the overall prevalence was 5.9%. Because of the age distribution, two populations were studied. In patients younger than 45, intravenous drug use was the only independent risk factor linked to serum anti-HCV positivity (Odds ratio: 151, CI 95%: 66.9-340). In patients older than 45, the independent risk factors were chronic liver disease (Odds ratio: 8.5, CI 95%: 4.4-16.8), per-endoscopic biopsies (Odds ratio: 2.7, CI 95%: 1.4-5.4), and blood transfusions (Odds ratio: 1.8, CI 95%: 0.9-3.5). Two variables were dominant for the entire population: IV drug use and chronic liver disease. In patients without these factors, only one risk factor was linked to serum anti-HCV positivity: perendoscopic biopsies (Odds ratio: 5.2, CI 95%: 1.6-16.5). These results suggest that HCV may be transmitted by perendoscopic biopsies.
ISSN:0399-8320