Fibronectin in cultured mouse sarcoma cells induced by foreign bodies

Indirect fluorescence was used to study distribution of fibronectin in cultured cells of 5 mouse foreign body-induced sarcomas (PS-4, PS-84, PS-100, PS-103, PS-130) and cells of early (2-3 months postimplantation) capsules surrounding implanted plastic films. Accumulation of pericellular or matrix f...

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Bibliographic Details
Published inBiulleten' eksperimental'noi biologii i meditsiny Vol. 98; no. 9; p. 339
Main Authors Liubimov, A V, Moĭzhess, T G
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.09.1984
Subjects
Animals
Cell Line
Cell Transformation, Neoplastic - analysis
Cells, Cultured
Fibronectins - analysis
Fluorescent Antibody Technique
Foreign-Body Reaction - complications
Mice
Mice, Inbred CBA
Polyvinyl Chloride
Sarcoma, Experimental - analysis
Sarcoma, Experimental - etiology
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Summary:Indirect fluorescence was used to study distribution of fibronectin in cultured cells of 5 mouse foreign body-induced sarcomas (PS-4, PS-84, PS-100, PS-103, PS-130) and cells of early (2-3 months postimplantation) capsules surrounding implanted plastic films. Accumulation of pericellular or matrix fibronectin in dense cultures compared to sparse ones was noted in all the lines except PS-84. In confluent cultures of these lines, a three-dimensional fibrillar network of fibronectin typical for fibroblast-like cells was observed. The pattern was very similar to that found in dense cultures of non-neoplastic early capsule cells. The data obtained show that loss of pericellular fibronectin would not serve as a marker of neoplastic transformation in this cellular system.
ISSN:0365-9615