A screening method for rapid detection of barbiturates in serum using tandem mass spectrometry

A mass spectrometric screening method for the detection of barbiturates in serum will be presented. Fragmentation of barbiturates under EI conditions leads to a loss of HNCO. Therefore, "neutral loss scans" of 43 u allow the indication of possibly existing representatives of this class of...

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Bibliographic Details
Published inBeitrage zur gerichtlichen Medizin Vol. 50; p. 99
Main Authors Bold, P, Brzezinka, H, Budzikiewicz, H
Format Journal Article
LanguageGerman
Published Austria 1992
Subjects
Barbiturates - pharmacokinetics
Humans
Mass Spectrometry
Pentobarbital - pharmacokinetics
Phenobarbital - pharmacokinetics
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Summary:A mass spectrometric screening method for the detection of barbiturates in serum will be presented. Fragmentation of barbiturates under EI conditions leads to a loss of HNCO. Therefore, "neutral loss scans" of 43 u allow the indication of possibly existing representatives of this class of compounds. Identification can be achieved by "daughter" or "parent ion scans". Thus, 10 micrograms/ml apro-, pento- and phenobarbital could be detected in serum.
ISSN:0067-5016