Cells that maintain long-term hematopoiesis in culture do not possess the capacity for regeneration following irradiation

It has been revealed by competitive repopulation assay that hemopoietic stem cells capable of supporting long-term hemopoiesis in the culture failed to regenerate after irradiation. 19 weeks after irradiation with 4 Gy the content of hemopoietic stem cells was 0.5% normal, while regeneration of CFUs...

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Bibliographic Details
Published inBiulleten' eksperimental'noi biologii i meditsiny Vol. 104; no. 7; p. 96
Main Authors Deriugina, E I, Drize, N I, Chertkov, I L
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.07.1987
Subjects
Animals
Bone Marrow - physiology
Bone Marrow - radiation effects
Bone Marrow Cells
Cells, Cultured
Colony-Forming Units Assay
Dose-Response Relationship, Radiation
Female
Hematopoiesis - radiation effects
Hematopoietic Stem Cells - physiology
Hematopoietic Stem Cells - radiation effects
Mice
Mice, Inbred C57BL
Mice, Inbred CBA
Mice, Inbred DBA
Regeneration - radiation effects
Time Factors
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Summary:It has been revealed by competitive repopulation assay that hemopoietic stem cells capable of supporting long-term hemopoiesis in the culture failed to regenerate after irradiation. 19 weeks after irradiation with 4 Gy the content of hemopoietic stem cells was 0.5% normal, while regeneration of CFUs was achieved up to subnormal level.
ISSN:0365-9615