Ultrastructural changes in the neuropile of the sensorimotor cortex during long-term protein-calorie deficiency

The effect of alimentary (protein-caloric) deficiency on the brain sensomotor cortex of mice was studied during their postnatal development. It was found that malnutrition of mice from day 10 to day 40 of postnatal period brought about the most remarkable changes in synaptic junctions located on the...

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Bibliographic Details
Published inBiulleten' eksperimental'noi biologii i meditsiny Vol. 95; no. 3; p. 108
Main Authors Medvedev, D I, Babichenko, I I, Eremina, I Z, Kravtsova, A I
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.03.1983
Subjects
Animals
Mice
Mice, Inbred CBA
Microscopy, Electron
Motor Cortex - ultrastructure
Neurofibrils - ultrastructure
Protein-Energy Malnutrition - pathology
Somatosensory Cortex - ultrastructure
Time Factors
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Summary:The effect of alimentary (protein-caloric) deficiency on the brain sensomotor cortex of mice was studied during their postnatal development. It was found that malnutrition of mice from day 10 to day 40 of postnatal period brought about the most remarkable changes in synaptic junctions located on the dendritic spines. They manifested destruction of the spine apparatus, reduction of the width of synaptic slits and of postsynaptic membranes. Dystrophic and destructive alterations are frequently encountered in dendrites, axon terminals, and myelinized axons, indicating the reduced compensatory functions of the CNS.
ISSN:0365-9615