Inhibitory effect of 18S ribosomal RNA of different origin on a wheat embryo cell-free translation system

The action of 18S rRNAs from three different sources--mouse reticulocytes, Ehrlich ascite carcinoma cells and wheat embryo--on cell-free translational system derived from wheat embryo was investigated. It is shown that all rRNA preparations have similar inhibitory action on translational activity of...

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Bibliographic Details
Published inMolekuliarnaia biologiia Vol. 14; no. 2; p. 323
Main Authors Karavanov, A A, Shifter, K, Khil'ko, S N, Makarovskaia, E E
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.03.1980
Subjects
Animals
Carcinoma, Ehrlich Tumor - analysis
Cell-Free System - drug effects
Depression, Chemical
Mice
Protein Biosynthesis - drug effects
Reticulocytes - analysis
RNA, Neoplasm - pharmacology
RNA, Ribosomal - isolation & purification
RNA, Ribosomal - pharmacology
Triticum - analysis
Triticum - metabolism
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Summary:The action of 18S rRNAs from three different sources--mouse reticulocytes, Ehrlich ascite carcinoma cells and wheat embryo--on cell-free translational system derived from wheat embryo was investigated. It is shown that all rRNA preparations have similar inhibitory action on translational activity of the system. This action is not dependent on the source of rRNA and mRNA by which the system is primed. Such a similarity of action strongly suggests a nonspecific mechanism of inhibition which may be based on polyanionic properties of RNA molecules.
ISSN:0026-8984