The effect of N-bromoacetamide on the components of sodium channel inactivation in the membrane of Ranvier's node

In voltage clamp experiments on the frog Ranvier node, the specific protein reagent, N-bromacetamide, significantly decelerates the sodium inactivation kinetics and makes it incomplete. After treatment with N-bromacetamide, both fast and slow inactivation time constants are increased and the proport...

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Published inFiziologicheskii zhurnal SSSR imeni I. M. Sechenova Vol. 77; no. 5; p. 53
Main Authors Lonskiĭ, A V, Krutetskaia, Z I, Roshchina, N G, P'iankova, S V
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.05.1991
Subjects
Acetamides - pharmacology
Animals
In Vitro Techniques
Membrane Potentials - drug effects
Membrane Potentials - physiology
Neurilemma - drug effects
Neurilemma - physiology
Perfusion - methods
Rana ridibunda
Ranvier's Nodes - drug effects
Ranvier's Nodes - physiology
Sodium Channels - drug effects
Sodium Channels - physiology
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Summary:In voltage clamp experiments on the frog Ranvier node, the specific protein reagent, N-bromacetamide, significantly decelerates the sodium inactivation kinetics and makes it incomplete. After treatment with N-bromacetamide, both fast and slow inactivation time constants are increased and the proportion of inactivation components is changed favouring the slowly inactivating one in the wide range of membrane potentials. The results are consistent with a single channel population following the 3-state model of inactivation.
ISSN:0015-329X