Morphology and cytodynamics of oxazolone-induced cellular immune response

Dynamics of lymphoid tissue changes induced by oxazolone, a contact allergen responsible for immune reaction of delayed type was studied. Basing on light-and electron microscopic findings and morphometrical analysis the following components of the reaction may be distinguished: an early active lymph...

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Bibliographic Details
Published inMorphologiai es igazsagugyi orvosi szemle Vol. 21; no. 3; p. 161
Main Authors Kalász, V, Németh, A
Format Journal Article
LanguageHungarian
Published Hungary 01.07.1981
Subjects
Animals
Cell Movement
Immunity, Cellular - drug effects
Lymph Nodes - drug effects
Lymph Nodes - immunology
Lymph Nodes - ultrastructure
Lymphocyte Activation
Male
Oxazoles - immunology
Oxazolone - immunology
Rats
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Summary:Dynamics of lymphoid tissue changes induced by oxazolone, a contact allergen responsible for immune reaction of delayed type was studied. Basing on light-and electron microscopic findings and morphometrical analysis the following components of the reaction may be distinguished: an early active lymphocytic migration, a delayed paracortex proliferation and a following follicular response. In the regulation of the outflow of lymphocytes a primary role may be attributed to the endothelial lining of the postcapillary venules. For the morphological changes of endothelial cells an effect of circulating antigen specific lymphocytes may be responsible.
ISSN:0540-889X