Structure of tryptic fragments of a neurotoxin from black widow spider venom

The N-terminal amino acid sequence of a neurotoxin from the venom of Latrodectus mactans tredecimguttatus (alpha-latrotoxin) was determined. Latrotoxin was subjected to the tryptic cleavage and total or partial amino acid sequences of 25 peptides were established. In total the tryptic fragments cont...

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Bibliographic Details
Published inBioorganicheskaia khimiia Vol. 17; no. 4; p. 437
Main Authors Volkova, T M, Galkina, T G, Kudelin, A B, Grishin, E V
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.04.1991
Subjects
Amino Acid Sequence
Animals
Black Widow Spider
Chromatography, High Pressure Liquid
Electrophoresis, Polyacrylamide Gel
Genes
Molecular Sequence Data
Peptide Mapping
Spider Venoms - genetics
Trypsin
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Summary:The N-terminal amino acid sequence of a neurotoxin from the venom of Latrodectus mactans tredecimguttatus (alpha-latrotoxin) was determined. Latrotoxin was subjected to the tryptic cleavage and total or partial amino acid sequences of 25 peptides were established. In total the tryptic fragments contained 252 amino acid residues. Essential structural information on cloning of the latrotoxin structural gene was obtained.
ISSN:0132-3423