Biologic effect of a hybrid preparation of human chorionic gonadotropin in human subjects

Alpha and beta-hCG subunits were recombined generating a hybrid hCG preparation (AB1ER-CR-2XY) which met the required specifications of a pharmaceutical product. The biologic activity contained in each vial of AB1ER-CR-2XY was equivalent to 10 000IU of hCG-IS. This preparation was given as a single...

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Bibliographic Details
Published inReproduccion Vol. 6; no. 2; p. 117
Main Author Rosemberg, E
Format Journal Article
LanguageEnglish
Published England 01.04.1982
Subjects
Adult
Chorionic Gonadotropin - administration & dosage
Chorionic Gonadotropin - therapeutic use
Drug Therapy, Combination
Female
Hormones - blood
Humans
Infertility, Female - blood
Infertility, Female - drug therapy
Menotropins - administration & dosage
Menstruation - drug effects
Ovary - drug effects
Protein Multimerization
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Summary:Alpha and beta-hCG subunits were recombined generating a hybrid hCG preparation (AB1ER-CR-2XY) which met the required specifications of a pharmaceutical product. The biologic activity contained in each vial of AB1ER-CR-2XY was equivalent to 10 000IU of hCG-IS. This preparation was given as a single dose of 10 000IU by the i.m. route to four female subjects presenting unexplained infertility. The hCG hybrid was demonstrated to effect gonadal stimulation in humans.
ISSN:0303-5220