Morphologic findings of the secretory epithelium of the ampulla following ethacrynic acid

The effect of ethacrynic acid (dose 60 mg./kg. and 100 mg./kg.) on the secretory epithelium of guinea pig ampulla and semicircular epithelium was investigated. With high doses of ethacrynic acid and after long periods (3-4 hours) only, discrete electron microscopic alterations were seen. These consi...

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Bibliographic Details
Published inLaryngologie, Rhinologie, Otologie Vol. 64; no. 4; p. 209
Main Author Hommerich, C P
Format Journal Article
LanguageGerman
Published Germany 01.04.1985
Subjects
Animals
Epithelium - drug effects
Epithelium - ultrastructure
Ethacrynic Acid - pharmacology
Guinea Pigs
Microscopy, Electron
Semicircular Canals - drug effects
Semicircular Canals - ultrastructure
Stria Vascularis - drug effects
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Summary:The effect of ethacrynic acid (dose 60 mg./kg. and 100 mg./kg.) on the secretory epithelium of guinea pig ampulla and semicircular epithelium was investigated. With high doses of ethacrynic acid and after long periods (3-4 hours) only, discrete electron microscopic alterations were seen. These consisted mainly in swelling of mitochondria, increase of vesicles, and movement or destruction of melanocytes. Interstitial oedema, well-documented in stria vascularis, was not observed.
ISSN:0340-1588