Epidemiology of cleft palate and cleft lip inthe Rhône-Alpes/Auvergne/Jura region. Apropos of 903 cases registered 1978-1987

Data from the Rhône-Alpes/Auvergne birth defects registry have been used to realise an epidemiological analysis of facial clefts (cleft palate and total cleft lip). Between 1978 and 1987, 903 cases have been ascertained giving an incidence of 0.67 per 1,000 for cleft lips with/without cleft palate (...

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Bibliographic Details
Published inPédiatrie (Paris ) Vol. 47; no. 2; p. 133
Main Authors Long, S, Robert, E, Laumon, B, Pradat, E, Robert, J M
Format Journal Article
LanguageFrench
Published France 1992
Subjects
Cleft Lip - epidemiology
Cleft Palate - epidemiology
Female
France - epidemiology
Humans
Infant, Newborn
Male
Parents
Registries - statistics & numerical data
Retrospective Studies
Sex Ratio
France
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Summary:Data from the Rhône-Alpes/Auvergne birth defects registry have been used to realise an epidemiological analysis of facial clefts (cleft palate and total cleft lip). Between 1978 and 1987, 903 cases have been ascertained giving an incidence of 0.67 per 1,000 for cleft lips with/without cleft palate (CLP) and 0.44 per 1,000 for cleft palates (CP). Several epidemiological characteristics have been studied: CLP are more frequent in males, and CP are more frequent in females. There is no detectable time trend, and birthweights are significantly lower in affected children than in the general population. There are more twins, more maternal epilepsy and more stimulations of ovulation in the studied sample than in the general population. The ranks of birth are higher in CP and CLP than in general population. The incidence of facial clefts in first degree relatives is 50 to 60 times the one in the general population, which is comparable to the literature findings.
ISSN:0031-4021