Effects of various caloric intakes on nitrogen metabolism of the body, the muscles and the viscera during total parenteral nutrition with aminoacidic solution enriched with branched-chain amino acids

Nitrogen metabolism was studied in ten injured/septic patients by means of a two compartment model, differentiating muscle from non muscle (central) tissue. During fasting muscle tissue loses a consistent amount of aminoacids which is retained in part by central tissue, giving rise to a positive nit...

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Bibliographic Details
Published inMinerva anestesiologica Vol. 55; no. 9; p. 349
Main Authors Iapichino, G, Colombo, A, Leoni, L, Marengo, M, Quarenghi, E, Radrizzani, D, Ravagnan, R, Rigoli, A, Veschi, G
Format Journal Article
LanguageItalian
Published Italy 01.09.1989
Subjects
Amino Acids, Branched-Chain - administration & dosage
Energy Intake
Fasting
Humans
Muscles - metabolism
Nitrogen - metabolism
Parenteral Nutrition, Total
Solutions
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Summary:Nitrogen metabolism was studied in ten injured/septic patients by means of a two compartment model, differentiating muscle from non muscle (central) tissue. During fasting muscle tissue loses a consistent amount of aminoacids which is retained in part by central tissue, giving rise to a positive nitrogen balance, whilst three methyl histidine and body nitrogen output are elevated. Total parenteral nutrition (glucose 15 kcal kg-1 day-1, nitrogen 0.30 g kg-1 die-1) improved body nitrogen balance and three methyl histidine excretion, but did not affect significantly either muscle or central nitrogen balance. Increasing caloric support to 30 kcal kg-1 day-1 did not showed any further effect on body nitrogen balance and three methyl histidine, while it improved significantly vs basal muscle nitrogen balance, but did not affect central nitrogen balance.
ISSN:0375-9393