Effects of a morphine-clomipramine combination on a test of experimental analgesia

Morphine (2.5 mg/kg sc) i.e. at a non-antinociceptive dose, augmented clomipramine-induced antinociceptive effect but failed to alter the values of clomipramine (10, 20, 40 mg/kg orally) levels in rats. These results suggest that the potentiation of clomipramine-induced analgesia by morphine does no...

Full description

Saved in:
Bibliographic Details
Published inRevue neurologique Vol. 141; no. 10; p. 669
Main Authors Montastruc, J L, Tran, M A, Guiol, C, Blanc, M, Gaillard, G, Cotonat, J, Montastruc, P
Format Journal Article
LanguageFrench
Published France 1985
Subjects
Analgesics
Animals
Clomipramine - pharmacology
Drug Synergism
Drug Therapy, Combination
Male
Morphine - pharmacology
Rats
Rats, Inbred Strains
Receptors, Opioid - metabolism
Online AccessGet more information

Cover

More Information
Summary:Morphine (2.5 mg/kg sc) i.e. at a non-antinociceptive dose, augmented clomipramine-induced antinociceptive effect but failed to alter the values of clomipramine (10, 20, 40 mg/kg orally) levels in rats. These results suggest that the potentiation of clomipramine-induced analgesia by morphine does not result from a peripheral pharmacokinetic mechanism but probably involves a central interaction between clomipramine and opiates pathways.
ISSN:0035-3787