The morphofunctional characteristics of the neurons in the sensorimotor cortex of old rabbits during the trace assimilation of rhythm

Extracellular neuronal activity was recorded from 460 neurons from alert young (5-7 months), middle-aged (54-65 months) and old (66-85 months) rabbits. Trace rhythmic activity of sensorimotor cortical neurons was examined after long-lasting (10-20 min) rhythmic (0.5-2 Hz) electrocutaneous stimulatio...

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Bibliographic Details
Published inZurnal vyss̆ej nervnoj dejatelnosti imeni I P Pavlova Vol. 42; no. 4; p. 710
Main Authors Kopytova, F V, Krivitskaia, G N, Mednikova, Iu S
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.07.1992
Subjects
Aging - physiology
Animals
Cell Count
Conditioning, Classical - physiology
Electric Stimulation
Fourier Analysis
Microelectrodes
Motor Cortex - cytology
Motor Cortex - physiology
Neurons - cytology
Neurons - physiology
Periodicity
Rabbits
Time Factors
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Summary:Extracellular neuronal activity was recorded from 460 neurons from alert young (5-7 months), middle-aged (54-65 months) and old (66-85 months) rabbits. Trace rhythmic activity of sensorimotor cortical neurons was examined after long-lasting (10-20 min) rhythmic (0.5-2 Hz) electrocutaneous stimulation of the contralateral forelimb. Spectral analysis of spike activity showed age-related differences in capability of producing a rhythm of previous stimulation in spontaneous neuronal activity. In young animals propriate rhythmic fluctuations of firing rate appeared after the first or second sessions of stimulations (on the first experimental day), in middle-aged ones--after 2-4 sessions (on the second or third days); cortical neurons in old rabbits did not exhibit trace rhythmic activity. Significant morphological changes in glial and neuronal cells were observed in sensorimotor cortex of old rabbits. It is proposed that morphological deteriorations may be the reason of the impairement of trace processes during aging.
ISSN:0044-4677