Use of enzyme substitutes in hypolactasia

The paper presents the results of clinical and laboratory studies of lactrase, a drug containing lactase. This agent is recommended for splitting lactic sugar in subjects with appreciably decreased production of endogenous lactase (hypolactasia). Twenty-eight patients with this condition were examin...

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Bibliographic Details
Published inKlinicheskaia meditsina Vol. 74; no. 8; p. 46
Main Authors Valenkevich, L N, Iakhontova, O I, Shubina, M E
Format Journal Article
LanguageRussian
Published Russia (Federation) 1996
Subjects
Adolescent
Adult
Aged
Aged, 80 and over
beta-Galactosidase - therapeutic use
Child
Child, Preschool
Humans
Lactase
Lactose - deficiency
Lactose Intolerance - blood
Lactose Intolerance - drug therapy
Lactose Tolerance Test
Middle Aged
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Summary:The paper presents the results of clinical and laboratory studies of lactrase, a drug containing lactase. This agent is recommended for splitting lactic sugar in subjects with appreciably decreased production of endogenous lactase (hypolactasia). Twenty-eight patients with this condition were examined. Manifest clinical symptoms of the condition were observed after loading with 50 g of lactose in all examinees. Addition of 250 mg of lactrase to lactose led to complete clinical compensation of the deficit of endogenous lactase in 75% examinees, and if 500 mg of lactrase was administered, hypolactasia was compensated in virtually all patients. A single intake of 50 g of lactose with lactrase causes a statistically reliable increase of glycemia in such patients. Moreover, a reliable effect of lactrase was observed when measuring galactose in the urine following the lactose test with 250 and 500 mg of lactrase. Our results indicate a high efficacy of lactrase in the treatment of patients with hypolactasia.
ISSN:0023-2149