The effect of fluorocitrate on oxygen consumption and Ca2+ transport in the mitochondria of liver cells

The effect of fluorocitrate on oxidative reactions and energy production systems of rat liver mitochondria has been studied. It was shown that oxidation of endogenous substrates and malate with pyruvate as well as the phosphorylation of the added ADP were inhibited by fluorocitrate. Inhibition of ox...

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Bibliographic Details
Published inT͡S︡itologii͡a Vol. 34; no. 11-12; p. 71
Main Authors Teplova, V V, Evtodienko, Iu V, Kholmukhamedov, E L, Sergeenko, N G, Goncharov, N V
Format Journal Article
LanguageRussian
Published Russia (Federation) 1992
Subjects
Animals
Biological Transport - drug effects
Calcium - metabolism
Calcium Channels - drug effects
Calcium Channels - metabolism
Citrates - pharmacology
Energy Metabolism - drug effects
In Vitro Techniques
Mitochondria, Liver - drug effects
Mitochondria, Liver - metabolism
Oxidative Phosphorylation - drug effects
Oxygen Consumption - drug effects
Rats
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Summary:The effect of fluorocitrate on oxidative reactions and energy production systems of rat liver mitochondria has been studied. It was shown that oxidation of endogenous substrates and malate with pyruvate as well as the phosphorylation of the added ADP were inhibited by fluorocitrate. Inhibition of oxygen consumption by fluorocitrate induced the efflux of Ca2+ ions from mitochondria and a decrease in the Ca(2+)-accumulating capacity. The effect of fluorocitrate on Ca2+ transport in mitochondria is due to activation of the Ca-efflux pathway in those sensitive to ruthenium red.
ISSN:0041-3771