Activation of arachidonic acid metabolism--a protective reaction of the body during irradiation and combined radiation-thermal damage

Metabolic activity of arachidonic acid cascade enzymes in rabbit polymorphonuclear leucocytes sharply rises during the first day of irradiation, decreases at the highest mortality period, and is restored at later times. The inhibitors of the activity of lipoxygenase and cyclooxygenase and the releas...

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Bibliographic Details
Published inRadiobiologiia Vol. 27; no. 6; p. 770
Main Authors Panosian, A G, Dzhinanian, K O, Gevondian, K V, Lebedeva, M N, Vartanian, G S
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.11.1987
Subjects
Animals
Arachidonic Acids - pharmacokinetics
Biotransformation
Burns - blood
Multiple Trauma - blood
Neutrophils - enzymology
Rabbits
Radiation Injuries, Experimental - blood
Rats
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Summary:Metabolic activity of arachidonic acid cascade enzymes in rabbit polymorphonuclear leucocytes sharply rises during the first day of irradiation, decreases at the highest mortality period, and is restored at later times. The inhibitors of the activity of lipoxygenase and cyclooxygenase and the release of arachidonic acid have been shown to increase the mortality rate and to decrease the average lifetime of rats exposed to ionizing radiation and a mixture of radiation and heat.
ISSN:0033-8192