Pathogenesis of the arterial hypertensive syndrome in Itsenko-Cushing disease

The indices of central hemodynamics and renin-angiotensine-aldosterone system, as well as their relationship, were studied in patients with aggravated Icenko-Cushing's disease. A stable high arterial pressure, a raised total peripheral resistance, a decreased cardiac index, an increased blood c...

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Bibliographic Details
Published inProblemy ėndokrinologii Vol. 28; no. 6; p. 28
Main Authors Komissarenko, I V, Slavnov, V N, Cheban, A K, Iakovlev, A A, Demchenko, N P
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.11.1982
Subjects
Adrenocorticotropic Hormone - blood
Aldosterone - blood
Cushing Syndrome - complications
Cushing Syndrome - physiopathology
Hemodynamics
Humans
Hypertension - etiology
Hypertension - physiopathology
Renin - blood
Renin-Angiotensin System
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Summary:The indices of central hemodynamics and renin-angiotensine-aldosterone system, as well as their relationship, were studied in patients with aggravated Icenko-Cushing's disease. A stable high arterial pressure, a raised total peripheral resistance, a decreased cardiac index, an increased blood corticotrophin, cortisol and aldosterone levels and an enhanced plasmatic renin activity were revealed. It is suggested that activation of the renin-angiotensin-aldosterone system stimulates the development of arterial hypertension in patients with Icenko-Cushing's disease, taking into account a significant role of this system in alteration of the central hemodynamics indices.
ISSN:0375-9660