Comparative analysis of primary structure of M-genes in remantadine-resistant and remantadine-sensitive strains of influenza virus A/FPV/Weybridge (H7N7) strains

• Published in: Bioorganicheskaia khimiia Vol. 13; no. 12; p. 1638
• Main Authors: Karginov, V A, Blinov, V M, Safronov, P F, Mamaev, L V, Golovin, S Ia
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01.12.1987
• Subjects: Adamantane - analogs & derivatives; Amino Acid Sequence; Animals; Base Sequence; Chick Embryo; DNA - genetics; DNA, Viral - genetics; Drug Resistance, Microbial; Genes, Viral; Influenza A virus - drug effects; Influenza A virus - genetics; Influenza A Virus, H7N7 Subtype; Molecular Sequence Data; Rimantadine - pharmacology; Viral Proteins - genetics

Full-length DNA copies of M-gene of remantadine-sensitive and remantadine-resistant variants of the influenza virus strain A/FPV/Weybridge (H7N7) have been synthesised and cloned. Complete nucleotide sequences of both cDNAs were determined by the Maxam-Gilbert method. There are three nucleotide subs...