Comparative analysis of primary structure of M-genes in remantadine-resistant and remantadine-sensitive strains of influenza virus A/FPV/Weybridge (H7N7) strains

Full-length DNA copies of M-gene of remantadine-sensitive and remantadine-resistant variants of the influenza virus strain A/FPV/Weybridge (H7N7) have been synthesised and cloned. Complete nucleotide sequences of both cDNAs were determined by the Maxam-Gilbert method. There are three nucleotide subs...

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Bibliographic Details
Published inBioorganicheskaia khimiia Vol. 13; no. 12; p. 1638
Main Authors Karginov, V A, Blinov, V M, Safronov, P F, Mamaev, L V, Golovin, S Ia
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.12.1987
Subjects
Adamantane - analogs & derivatives
Amino Acid Sequence
Animals
Base Sequence
Chick Embryo
DNA - genetics
DNA, Viral - genetics
Drug Resistance, Microbial
Genes, Viral
Influenza A virus - drug effects
Influenza A virus - genetics
Influenza A Virus, H7N7 Subtype
Molecular Sequence Data
Rimantadine - pharmacology
Viral Proteins - genetics
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Summary:Full-length DNA copies of M-gene of remantadine-sensitive and remantadine-resistant variants of the influenza virus strain A/FPV/Weybridge (H7N7) have been synthesised and cloned. Complete nucleotide sequences of both cDNAs were determined by the Maxam-Gilbert method. There are three nucleotide substitutions, two of which lead to amino acid changes in M1 and M2 proteins. The existence of M3 protein, a polypeptide 68 amino acids long, encoded by the negative strand of RNA, is suggested. Amino acid changes in M2 and M3 proteins and their relation to the remantadine resistance are discussed.
ISSN:0132-3423