Mutagenicity of N-nitrosopiperazine derivatives in Saccharomyces cerevisiae

The mutagenic properties of 8 N-nitrosopiperazines were examined in Saccharomyces cerevisiae. Forward mutations to canavanine resistance and reversions of his1-7 were induced by N'-methyl-N-nitrosopiperazine, dinitrosopiperazine, 2-methyldinitrosopiperazine, 2,5-dimethyldinitrosopiperazine, and...

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Bibliographic Details
Published inMutation research Vol. 77; no. 2; p. 143
Main Authors Larimer, F W, Hardigree, A A, Lijinsky, W, Epler, J L
Format Journal Article
LanguageEnglish
Published Netherlands 01.02.1980
Subjects
Canavanine - pharmacology
Drug Evaluation, Preclinical
Drug Resistance, Microbial
Genetic Techniques
Mutagens
Phenotype
Piperazines - pharmacology
Saccharomyces cerevisiae - genetics
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Summary:The mutagenic properties of 8 N-nitrosopiperazines were examined in Saccharomyces cerevisiae. Forward mutations to canavanine resistance and reversions of his1-7 were induced by N'-methyl-N-nitrosopiperazine, dinitrosopiperazine, 2-methyldinitrosopiperazine, 2,5-dimethyldinitrosopiperazine, and 2,6-dimethyldinitrosopiperazine, in the presence of rat-liver homogenate. N-nitrosopiperazine, 2,3,5,6-tetramethyldinitrosopiperazine, and 4-benzoyl-3,5-dimethyldinitrosopiperazine were non-mutagenic.
ISSN:0027-5107