The role of monoamin- and acidergic mechanisms of the hippocampus in anxiety states of different origins and their participation in the antiaversive effects of anxiolytics

• Published in: Fiziologicheskii zhurnal imeni I.M. Sechenova Vol. 79; no. 1; p. 99
• Main Authors: Talalaenko, A N, Krivobok, G K, Stakhovskiĭ, Iu V
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01.01.1993
• Subjects: Animals; Anti-Anxiety Agents - therapeutic use; Anxiety - chemically induced; Anxiety - drug therapy; Anxiety - physiopathology; Avoidance Learning - drug effects; Avoidance Learning - physiology; Chlordiazepoxide - therapeutic use; Disease Models, Animal; Dopamine; Drug Evaluation, Preclinical; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Hippocampus - drug effects; Hippocampus - physiopathology; Male; Rats; Receptors, Cell Surface - drug effects; Receptors, Cell Surface - physiology; Serotonin

The experiments on rats with tests of avoiding "lighting square" and "threatening situation" and with the chemical stimulation of dorsal and ventral hippocampus with dopamine, 5-HT, GABA and glutamine acid, showed different functional significance of these monoamines and acidergi...