The role of monoamin- and acidergic mechanisms of the hippocampus in anxiety states of different origins and their participation in the antiaversive effects of anxiolytics

The experiments on rats with tests of avoiding "lighting square" and "threatening situation" and with the chemical stimulation of dorsal and ventral hippocampus with dopamine, 5-HT, GABA and glutamine acid, showed different functional significance of these monoamines and acidergi...

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Bibliographic Details
Published inFiziologicheskii zhurnal imeni I.M. Sechenova Vol. 79; no. 1; p. 99
Main Authors Talalaenko, A N, Krivobok, G K, Stakhovskiĭ, Iu V
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.01.1993
Subjects
Animals
Anti-Anxiety Agents - therapeutic use
Anxiety - chemically induced
Anxiety - drug therapy
Anxiety - physiopathology
Avoidance Learning - drug effects
Avoidance Learning - physiology
Chlordiazepoxide - therapeutic use
Disease Models, Animal
Dopamine
Drug Evaluation, Preclinical
gamma-Aminobutyric Acid
Glutamates
Glutamic Acid
Hippocampus - drug effects
Hippocampus - physiopathology
Male
Rats
Receptors, Cell Surface - drug effects
Receptors, Cell Surface - physiology
Serotonin
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Summary:The experiments on rats with tests of avoiding "lighting square" and "threatening situation" and with the chemical stimulation of dorsal and ventral hippocampus with dopamine, 5-HT, GABA and glutamine acid, showed different functional significance of these monoamines and acidergic transmitters agents in the states of anxiety of heteromodal aversive genesis. It seems that the variations in the action spectrum of anxiolytics under study are due to unequal degree of 5-HT and GABA-ergic transmitter mechanisms of dorsal and ventral hippocampus.
ISSN:1027-3646