Amplification of the erbb-2 (Her-2/NEU), erbb-1 (HER-1) and c-myc oncogenes is often combined with the deletion of the short arm of chromosome 17 in human carcinoma

Amplification of oncogenes erbb-2, erbb-1, c-myc and losses of heterozygosity (LOH) at chromosomes 11p (probe hras-1), 17p (probe ynz-22) and 17q (probe thh-59) were studied in 165 human tumours (60 breast, 22 ovary, 40 colorectal, 23 lung, and 20 thyroid carcinomas). The correlation (P < 0.01) b...

Full description

Saved in:
Bibliographic Details
Published inMolekuliarnaia biologiia Vol. 27; no. 4; p. 888
Main Authors Imianitov, E N, Chernitsa, O I, Nikiforova, I F, Serova, O M, Sokolov, S I, Laur, O Iu, Togo, A V, Kniazev, P G
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.07.1993
Subjects
Chromosome Deletion
Chromosomes, Human, Pair 11
Chromosomes, Human, Pair 17
DNA, Neoplasm - genetics
Gene Amplification
Genes, myc
Heterozygote
Humans
Neoplasms - genetics
Proto-Oncogene Proteins - genetics
Receptor, Epidermal Growth Factor
Receptor, ErbB-2
Online AccessGet more information

Cover

More Information
Summary:Amplification of oncogenes erbb-2, erbb-1, c-myc and losses of heterozygosity (LOH) at chromosomes 11p (probe hras-1), 17p (probe ynz-22) and 17q (probe thh-59) were studied in 165 human tumours (60 breast, 22 ovary, 40 colorectal, 23 lung, and 20 thyroid carcinomas). The correlation (P < 0.01) between the increased copy number of mentioned oncogenes and LOH at 17p was demonstrated for tumours tested: extra copies of these oncogenes were revealed in 11 of 46 DNA specimens with LOH on ynz-22, but only in 3 of 61 without LOH. This correlation was mostly due to frequent combinations between erbb-2 amplification and 17p deletions; the incidence of increased copy number of erbb-1 and c-myc oncogenes was not high enough for final conclusions about the association of their alterations with LOH at chromosome 17p.
ISSN:0026-8984