Effect of rhG-CSF on platelets using in vitro bleeding time and transcranial Doppler examination

There is experimental evidence for recombinant human granulocyte colony-stimulating factor (rhG-CSF)-induced stimulation of hemostaseologic parameters including platelets. Using the closure time of the in vitro bleeding test (IVBT, Thrombostat 4000, VDG, Seeon) and different hemostaseologic paramete...

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Bibliographic Details
Published inBeiträge zur Infusionstherapie und Transfusionsmedizin = Contributions to infusion therapy and transfusion medicine Vol. 34; p. 161
Main Authors Söhngen, D, Siebler, M, Wienen, S, Kobbe, G, Hollmig, K, Schneider, P, Boogen, C, Heyll, A, Schneider, W
Format Journal Article
LanguageGerman
Published Switzerland 1997
Subjects
Adolescent
Adult
Bleeding Time
Blood Donors
Blood Platelets - drug effects
Female
Granulocyte Colony-Stimulating Factor - pharmacology
Humans
Intracranial Embolism and Thrombosis - blood
Intracranial Embolism and Thrombosis - diagnostic imaging
Leukocyte Count
Male
Middle Aged
Platelet Count
Platelet Function Tests
Recombinant Proteins
Risk Factors
Ultrasonography, Doppler, Transcranial
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Summary:There is experimental evidence for recombinant human granulocyte colony-stimulating factor (rhG-CSF)-induced stimulation of hemostaseologic parameters including platelets. Using the closure time of the in vitro bleeding test (IVBT, Thrombostat 4000, VDG, Seeon) and different hemostaseologic parameters, our results are suggestive of a directly or indirectly induced in vivo stimulation of platelets following rhG-CSF stimulation in healthy stem cell donors. According to the negative transcranial Doppler microembolic monitoring of the middle cerebral artery, there is no evidence for clinically silent cerebral microembolism supporting a prothrombotic state facilitating the formation of arterial thrombi with subsequent cerebral embolization.
ISSN:1023-2028