Changes in phospholipid composition of high density lipoproteins in children as a possible precursor of the development of ischemic heart disease

The proportion of apoprotein-AI (apo-AI) phospholipids (PL) and HDLP phospholipid spectrum were determined in addition to principal coronary risk factors; cholesterol (CS), triglycerides (TG) and high-density lipoprotein (HDLP) CS, in high-risk children, whose parents had survived myocardial infarct...

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Bibliographic Details
Published inKardiologiia Vol. 28; no. 9; p. 61
Main Authors Gerasimova, E N, Ozerova, I N, Aingorn, E D, Sipiagina, A E, Belokon', N A
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.09.1988
Subjects
Adolescent
Adult
Child
Coronary Disease - etiology
Coronary Disease - genetics
Female
Humans
Hypolipoproteinemias - complications
Hypolipoproteinemias - genetics
Lipoproteins, HDL - blood
Male
Middle Aged
Phosphatidylcholines - blood
Phosphatidylcholines - deficiency
Risk Factors
Sex Factors
Sphingomyelins - blood
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Summary:The proportion of apoprotein-AI (apo-AI) phospholipids (PL) and HDLP phospholipid spectrum were determined in addition to principal coronary risk factors; cholesterol (CS), triglycerides (TG) and high-density lipoprotein (HDLP) CS, in high-risk children, whose parents had survived myocardial infarction at a young age, and also in children with vegetovascular dystonia and a control group. It is demonstrated that children with relatively low percentage of lecithin in HDLP, in the absence of changes in CS, TG, apo-B and apo-AI, and HDLP CS, could be found in all the examined groups, and were particularly numerous in the high-risk group. Correlations coefficients for the HDLP PL percentage in the father-child, mother-child and father-mother pairs were estimated, revealing a positive correlation with respect to lecithin in these pairs, an evidence of the contribution of the general familial environment to the variability of the parameter in question in the examined groups. Different correlations were demonstrated between lecithin/sphingomyelin and lecithin/kephalin ratios in boys and girls from the control and high-risk groups.
ISSN:0022-9040